This research will Assess the pharmacological exercise of PF-06305591 in balanced male volunteers by examining the results of two dose amounts of PF-06305591 on cold discomfort depth evoked by holding non-dominant hand into a water bathtub held at 2+/- levels. System for planning in vivo formulation：Acquire μL DMSO grasp liquid, https://haimj654udm5.thecomputerwiki.com/user