There is a release of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors inside the dorsal horn to lower afferent soreness transmission and make analgesia. Thus, medicine like clonidine that focus on alpha-two receptors can influence the transmission of ache. Clonidine is distributed in breast milk; https://scottv157tkg7.blogdosaga.com/profile