Pentobarbital will reduce the extent or outcome of saxagliptin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Mysterious. pentobarbital will decrease the level or result of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minimal/Importance Unknown. With therapeutic doses of TCAs, barbiturates enhance metabolism and decrease blood concentrati... https://roselynei366bob2.livebloggs.com/profile