You will find there's release of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors during the dorsal horn to lessen afferent discomfort transmission and produce analgesia. For that reason, medicines like clonidine that focus on alpha-2 receptors can affect the transmission of discomfort. Intense Allergic Reactions. https://www.proleviate.com/post/the-new-pain-killer-conolidine