Study into conolidine has triggered discovery of an opioid receptor in your body known as ACKR3/CXCR7. ACKR3 is apparently the most desired target for conolidine, which also disregards another four classical opioid receptors(three). Conolidine has become present in the tabernaemontana divaricata plant, which happens to be within the Apocynaceae https://www.proleviate.com/post/conolidine-an-alternative-natural-pain-relief-to-replace-traditional-painkillers